Featured Publications
​
Luo, H.*, Cortés-López, M.*, Tam, C.L., Xiao, M., Wakiro I., Chu K.L., Pierson, A., Chan, M., Chang, K., Yang, X., Han G., Ahn E.E., Morris Q.D., Landau D.A., Kharas, M.G. (* equal contribution, co-first author)
SON is an Essential m6A Target for Hematopoietic Stem Cell Fate. Cell Stem Cell, Volume 30, Issue 12, 7 December 2023, Pages 1658-1673.e10
​​Chavez, F.H., Luo, H., Cifani, P., Pine, A., Chu, K.L., Joshi, S., Barin, E., Schurer, A., Chan, M., Chang, K., Han, G.Y., Pierson, A.J., Xiao, M., Yang, X., Kuehm, L.M., Hong, Y., Nguyen, D., Chiosis, G., Kentsis, A., Leslie, C., Vu, L.P., Kharas, M.G.
RNA binding protein SYNCRIP maintains proteostasis and self-renewal of hematopoietic stem and progenitor cells. Nature Communications, 2023, 14, 2290
Kotini, A.G., Carcamo, S., Rodriguez, N.C., Olszewska, M., Wang, T., Demircioglu, D., Chang, C.J., Bernard, E., Chao, M.P., Majeti, R., Luo, H., Kharas, M.G., Hasson, D., Papapetrou, E.P.
Patient-Derived iPSCs Faithfully Represent the Genetic Diversity and Cellular Architecture of Human Acute Myeloid Leukemia. Blood Cancer Discovery. 2023, 4 (4): 318–335.
​
Cheng, Y., Xie, W., Pickering, B.F., Chu, K.L., Savino, A.M., Yang, X., Luo, H., Nguyen, D., Mo, S., Barin, E., Velleca, A., Rohwetter, T.M., Patel, D.J., Jeffrey, S.R., Kharas, M.G.
N6-Methyladenosine on mRNA facilitates a phase-separated nuclear body that suppresses myeloid leukemic differentiation. Cancer Cell. 2021, Volume 39, Issue 7, pages 958-972 e8
​
He, M.*, Chiang, H.H.*, Luo, H.*, Zheng, Z.*, Ohkubo, R., Susanto, A., Chen, D. (* equal contribution, co-first author)
An Acetylation switch of the NLRP3 inflammasome regulates aging- and overnutrition associated chronic inflammation and insulin resistance. Cell Metabolism, 2020, Volume 31, Issue 3, pages 580-591.E5
Wesely, J., Kotini, A.G.#, Izzo, F.#, Luo, H.#, Yuan, H.#, Sun, J., Georgomanoli, M., Zviran, A., Deslauriers, A.G., Dusaj, N., Nimer, S.D., Leslie, C., Landau, D.A., Kharas, M.G.*, Papapetrou, E.P.* (# equal contribution, co-second author)
Acute Myeloid Leukemia iPSCs reveal a role for RUNX1 in the maintenance of human Leukemia Stem Cells. Cell Reports, 2020, 31(9):107688.
Cheng, Y.*, Luo, H.*, Izzo, F.*, Pickering, B.F., Nguyen, D., Myers, R., Schurer, A., Gourkanti, S., Bruning, J.C., Vu, L.P., Jeffrey, S.R., Landau, D.A., Kharas, M.G. (* equal contribution, co-first author)
m6A RNA Methylation Maintains Hematopoietic Stem Cell Identity and Symmetric Commitment. Cell Reports, 2019, Volume 28, Issue 7, pages 1703-1716 e6
​
Luo, H., Mu, W.C., Karki, R., Chiang, H.H., Mohrin, M., Shin, J., Ohkubo, R., Ito, K., Kanneganti, T.D., Chen, D.
Mitochondrial stress-initiated aberrant activation of the NLRP3 inflammasome regulates hematopoietic stem cell aging. Cell Reports, 2019, Volume 26, Issue 4, pages 945-954 e4
Mohrin, M., Widjaja, A., Liu, Y., Luo, H., Chen, D.
The mitochondrial unfolded protein response is activated upon hematopoietic stem cell exit from quiescence. Aging Cell, 2018, 17 (3), e12756
​Mohrin, M.*, Shin, J.*, Liu, Y.*, Brown, K.*, Luo, H., Xi, Y., Haynes, C.M., Chen, D.
A mitochondrial UPR-mediated metabolic checkpoint regulates hematopoietic stem cell aging. Science. 2015, Volume 347, No. 6228, pages 1374-1377
Shin, J.*, He, M.*, Liu, Y.*, Paredes, S.*, Villanova, L., Brown, K., Qiu, X., Nabavi, N., Mohrin, M., Wojnoonski, K., Li, P., Cheng, H.W., Murphy, A.J., Valenzuela, D.M., Luo, H., Kapahi, P., Krauss, R., Mostoslavsky, R., Yancopoulos, G.D., Alt, F.W., Chua, K.F., Chen, D.
SIRT7 represses Myc activity to suppress ER stress and prevent fatty liver disease. Cell Reports. 2013, Volume 5, Issue 3, pages 654-665
​
Review and Preview Articles
Luo, H., Kharas, M.G.
Dotting out AML by targeting Fibrillarin. Cancer Research. 2024, Epub ahead of print
Luo, H., Kharas, M.G.
Decoding m6A, One Reader at a Time. Haematologica. 2021, Epub ahead of print
Cheng, Y., Luo, H., Kharas, M.G.
Rubbing Out Leukemia Stem Cell by Erasing the Erasers. Cell Stem Cell. 2020, Volume 27, Issue 1, pages 3-5
Luo, H., Chiang, H.H., Louw, M., Susanto, A., Chen, D.
Nutrient sensing and the oxidative stress response. Trends in Endocrinology and Metabolism. 2017, Volume 28, Issue 6, pages 449-460